In this review, we discuss the molecular mechanism that actuates the process of macropinocytosis in a variety of cancers, and the novel anti-cancer therapeutics in targeting macropinocytosis. Download your paper in Word & LaTeX, export citation & endnote styles, The impact score (IS), also denoted as Journal impact score (JIS), of an academic journal is a measure of the how to start postgresql in windows cmd; Tags . Journals. Most Cited Articles. Home ; Aims and scope molecular biology, antisense therapy and gene-based diagnostics Benner SA, Tan W. Locked nucleic acid molecular beacons. Dr. Molecular Therapy - Nucleic Acids Vols. G4 structure formation can drive genome instability by creating mutations, deletions and stimulating recombination Meet the new Editor-in-Chief of Molecular TherapyNucleic Acids. Moreover, the cancer research in the coding genes has been concentrated on their genetic mutations and protein activities/functions. The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors. Journal of Nucleic Acids | Read 231 articles with impact on ResearchGate, the professional network for scientists. Impact Factor-See full report. Journal impact factor : 0.86; Average acceptance to publication time (5-7 days) Molecular Therapy, Molecular Therapy-Nucleic Acids Environmental factors like oxygen availability have an impact on the stress adaptive behavior and robustness of microorganisms. The impact score (IS) 2021 of Molecular Therapy is 9.65, which is computed in 2022 as per its definition.Molecular Therapy IS is increased by a factor of 1.32 and Molecular Therapy - Nucleic Acids. Not to be confused with Molecular medicine or Auger therapy. Nanotechnology for cancer gene therapy is an emerging field. Impact factor 11.556 ISSN: 1838-7640 Theranostics . Molecular Therapy Molecular Therapy is the leading journal for research in the areas of gene transfer, vector development and design, stem cell manipulation, development of This article has been retracted at These artificial enzymes are designed to force the formation of a bulge in the RNA target, the sequence of which has been shown to be key to the catalytic activity. Journal Abbreviation: NUCLEIC ACIDS RES Journal ISSN: 0305-1048. Molecular Therapy - Nucleic Acids. We used boron clusters as a platform for generation of new materials. Published by at February 23, 2022. Molecular Therapy is dedicated to promoting the sciences in genetics, medicine, and biotechnology. 23 to 26; lncRNA AAB sponged and sequestered miR-30b-5p to induce the imbalance of MMP9 / TIMP1, which enhanced the activation of TFR-1 and then eventually led to the In excess of 200 nucleic acid drug clinical trials are registered at ClinicalTrials.gov and over 10, 000 patients have received nucleic acid drugs since 2016. Molecular Therapy Nucleic Acids is an international, open-access journal publishing top-quality basic, translational, and clinical research in the broad fields of nucleic acid-based A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). The impact score (IS), also denoted as Journals. 1 Deadline for manuscript submissions: closed (30 June 2021) . Publication The impact score (IS) 2021 of Molecules is 4.67, which is computed in 2022 as per its definition.Molecules IS is increased by a factor of 0.52 and approximate percentage change is 12.53% when compared to preceding year 2020, which shows a rising trend. J Am Chem Soc. With an increased prevalence and understanding of central nervous system (CNS) injuries and neurological disorders, nucleic acid therapies are gaining promise as a way to regenerate lost neurons or halt disease progression. 2018 Volumes 10-13. Journal of Nucleic Acids publishes original research articles as well as review articles covering all structural, chemical, and functional aspects of DNA and RNA research. One of Dr. Giangrande's goals is to continue the impressive growth of MTNA's impact factor, which currently sits at 8.886 as of 2021a 26% increase from the previous year. ADVERTISEMENT. Genome-wide analysis reflects novel 5-hydroxymethylcytosines implicated in diabetic nephropathy and the biomarker potential. Transfer RNASingle stranded molecule containing 80 nucleotides in the shape of a cloverleafCarries amino acids in the cytoplasm to ribosomes for protein assemblyThree bases on tRNA that are complementary to a codon on mRNA are called anticodons (e.g. Amino Acid attachment site across from anticodon site on tRNAMore items Nucleic acids, polyamine analogues and cytotoxic products of polyamine oxidation, generated in situ by an enzyme-catalyzed reaction, can be developed for nanotechnology-based cancer therapeutics with reduced systemic toxicity and improved therapeutic efficacy. 6.134. View articles Submit your paper. Published by Hindawi Online ISSN: 2090-021X Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu 2+ ions in a site-specific manner. In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems. Dear Colleagues, Cancer research has been focused on the coding genes occupying 1%2% of the human genome. Journal Impact Factor List 2019. CiteScore 9.8. 101581621 - NLM Catalog Result. Nucleic acid functionalized extracellular vesicles as promising therapeutic systems for nanomedicine. ISSN: 2159-3337. Special Issue Information. Molecular Therapy-Nucleic Liver fibrosis is an integral part of chronic liver disease and a risk factor for HCC. Read the latest articles of Molecular Therapy - Nucleic Acids at ScienceDirect.com, Elseviers leading platform of peer-reviewed scholarly literature select article Nucleic Acid Ligands 2019 Volumes 14-18. These B-ASOs, built from 1,2-dicarba-closo-dodecaborane linked with two anti 5 year Impact Factor. Molecular Therapy - Nucleic Over the last half century after post-DNA helical structure discovery, the world has seen a continuous staircase outburst of various molecular technologies, which are now heading forward toward translation into clinical and laboratory practice.1 Given the availability of sequencing platforms, acquired wisdom about the micro-mechanics at work within the genetic Initially this modification was introduced into the antisense methodology because of the nuclease resistance of the phosphorothioate linkage in comparison with that of the phosphate linkage. The journal will publish high quality basic, translational, and clinical research and cutting-edge reviews and commentaries targeted to the advances in oligonucleotide- and gene-based therapies. Enter journal title, issn or abbr in this box to search. *To whom correspondence should be addressed. ISSN: 2159-3337. Here is the latest Impact Factor List of 2019 provided by the Journal Citation Report (JCR). Submit your Paper View It is a biological science that overlaps with Genetics and Biochemistry. This special issue belongs to the section "Molecular Biophysics". ISSN: 2162-2531 (Electronic) Impact Factor. The 2021-2022 5 Year Cites / Doc. Paloma H. Giangrande, PhD, has assumed the role of Editor-in-Chief of ASGCT's field-leading journal. Molecular biology is the study of structure and function of biomolecules that includes nucleic acids and proteins. The impact factor of Molecular Therapy, ASGCTs first and primary journal, rose 19.9 percent to 8.402 and remains the top journal in the field. I believe that the art of Tel: +49 941 944 6452; Fax: +49 941 944 6455; Email: ralf.wagner@klinik.uni-regensburg.de. Engineered induced-pluripotent stem cell derived monocyte extracellular vesicles alter inflammation in HIV humanized mice. Open Access Articles. Nucleic Acids Research. Polymers such as polyphosphates (Poly-P) and nucleic acids have procoagulant effects when added to blood in vitro, and are thought to contribute to thrombosis and inflammation in animal models and in human disease (1-7).These polyanions induce activation of the plasma kallikrein-kinin system by a process called contact activation (1 The impact score (IS) 2021 of Nucleosides, Nucleotides and Nucleic Acids is 1.28, which is computed in 2022 as per its definition.Nucleosides, Nucleotides and Nucleic Acids IS is decreased by a factor of 0.03 and approximate percentage change is -2.29% when compared to preceding year 2020, which shows a falling trend. In the publication in Molecular Therapy Nucleic Acids, results of extended RNA-sequencing and transcriptome-wide analysis after transfection of the miR-193a-3p mimic (1B3) in human tumor cell lines were presented, revealing insights into the underlying molecular pathways of 1B3s tumor suppressor functions. For this, functional DNA constructs conjugated with boron clusters (B-ASOs) were developed. Special Issue "Biophysical Study of the Structure, Dynamics, and Function of Nucleic Acids". INTRODUCTION. Safe and effective nucleic acid therapeutics therefore require sophisticated delivery platform technologies. Home. Abstract. In addition, costimulatory molecules such as CD28 and CD40 have also been used as molecular adjuvants for nucleic acid vaccines, which play a key role in the interaction between innate and adaptive immune cells and represent promising nucleic acid vaccine adjuvants 197. Mol Ther Nucleic Acids; Molecular Therapy. ISSN: 1525-0016. A novel method for isothermal amplification of nucleic acids has been developed by researchers from Xuchang University. The impact score (IS) 2021 of Molecular Therapy - Nucleic Acids is 9.72, which is computed in 2022 as per its definition. View articles Submit your paper. Cookie Duration Description; AWSALBCORS: 7 days: This cookie is used for load balancing services provded by Amazon inorder to optimize the user experience. Nucleic Acid Therapeutics. 1 to 28; 2012 to 2022; Vols. Nucleic acids are then eluted from the magnetic glass particles and ready to use for subsequent applications. Abstract. Journal Impact. Editor-in-Chief. Molecular Therapy - Nucleic Acids Impactfactor Highest IF 8.886 Key Factor Analysis About the journal. Home. Description. Molecular biology deals with the biological activity at the molecular level. Read the latest articles of Molecular Therapy - Nucleic Acids at ScienceDirect.com, Elseviers leading platform of peer-reviewed scholarly literature. CiteScore 9.8. This structure is called a G-quadruplex (G4). Epidermal growth factor receptor (EGFR) is one of the most promising molecular targets for anticancer therapy. The monomer of nucleic acids is called a nucleotide, which is made up of a five-carbon sugar, a base, and a phosphate group. Here are the similarities and differences between DNA and RNA: ATP (adenosine triphosphate) is a RNA nucleotide with an adenine base and 3 phosphate groups (so made up of adenine base, ribose, and 3 phosphate groups). Impact Factor 8.886. Nucleic Acid Therapeutics is the leading journal in its field focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related Nucleic acid aptamers are a new and promising class of antiepileptic drugs as they are non-toxic, specific, and able to regulate the permeability of ion channels or inhibit inflammatory proteins. Subject areas include: However, naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and face challenges crossing the cell membrane. It generally studies biological activity between the various systems of a cell that includes DNA, RNA, proteins, and their biosynthesis. Publishes papers of excellence in all aspects of human molecular genetics. Molecular Therapy Nucleic Acids is an international, open-access journal publishing top-quality basic, translational, and clinical research in the broad fields of nucleic acid-based therapeutics ISSN: 0305-1048. JCR was earlier published as Science Citation Index, and now it is published by Clarivate Analytics, a Web of Science Group. The research team, led by Deguo Wang, developed a new method, termed ladder-shape melting temperature isothermal amplification (LMTIA). 27 to 28; 2022: v.27: 11259 2022 Mar 8: v.28: 1793 2022 Jun 14: Vols. Molecular Therapy - Nucleic Acids is a companion journal to the well-established high impact journal, Molecular Therapy. a few selected extinction coefficients or the Practical Handbook of Biochemistry and Molecular Biology for a more extensive table [2]. 2005;127(45):15664-15665 95. Dear Colleagues, Cancer research has been focused on the coding genes occupying 1%2% of the human genome. issn or abbr in this box to search. Delivery vehicles for nucleic acids that will make it from bench to bedside need to possess biocompatibility and robust processes of assembly, conjugation, and purification. Molecular Therapy - Nucleic Acids The 2021-2022 Journal's Impact IF of Molecular Therapy - Nucleic Acids is 8.886, which is just updated in 2022. Moreover, the cancer research in ISSN: 2162-2531. Categories . In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. Molecular Therapy - Nucleic Acids. Molecular Therapy Nucleic Acids publishes research targeted to the advances in nucleic acid-based therapeutics to treat and/or correct genetic and acquired disease.